MRC Integrative Epidemiology Unit

MRC IEU Shiny apps

R/Shiny web applications developed at the MRC Integrative Epidemiology Unit. Original location: mrcieu.mrsoftware.org

Polygenic risk score & phenome atlases

Explore associations between genetic scores and human traits.

Polygenic risk scores

PRS Atlas

Explore associations between 162 polygenic risk scores and 551 heritable traits in the UK Biobank. An interactive resource for investigating patterns across the human phenome.

  • 162 risk scores
  • 551 traits
  • UK Biobank
Metabolic biomarkers

Metabolites PRS Atlas

Investigate relationships between genetic liabilities and circulating metabolic biomarkers, including insights into the human lipidome.

  • Genetic liability
  • Metabolomics
  • Lipidome

Mendelian randomization atlases

Investigate tissue regulation and immune-cell traits using genetic evidence.

Tissue & gene regulation

Tissue MR Atlas

Explore tissue-dependent regulatory mechanisms through transcriptome-wide Mendelian randomization, connecting gene expression with traits across tissues.

  • Gene expression
  • Tissue regulation
  • Transcriptome-wide MR
Immune-cell traits

Immuno MR Atlas

Browse Mendelian randomization and colocalization results for immune-cell traits, bringing together genetic evidence to investigate immune biology.

  • Immune cells
  • Mendelian randomization
  • Colocalization